https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Androgen receptor is dispensable for x-zone regression in the female adrenal but regulates post-partum corticosterone levels and protects cortex integrity https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45206 Cyp11a1-Cre to specifically ablate AR from the mouse adrenal cortex. Results show that AR-signaling is dispensable for adrenal gland development in females, and for X-zone regression during pregnancy, but is required to suppress elevation of corticosterone levels post-partum. Additionally, following disruption to adrenal AR, aberrant spindle cell development is observed in young adult females. These results demonstrate sexually dimorphic regulation of the adrenal X-zone by AR and point to dysfunctional adrenal androgen signaling as a possible mechanism in the early development of adrenal spindle cell hyperplasia.]]> Wed 26 Oct 2022 17:41:19 AEDT ]]> Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45093 Wed 26 Oct 2022 12:23:52 AEDT ]]> Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36575 Tue 09 Jun 2020 11:47:41 AEST ]]> Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38075 Mon 14 Nov 2022 17:48:07 AEDT ]]> A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45503 Fri 28 Oct 2022 16:07:11 AEDT ]]> Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44473 Fri 14 Oct 2022 08:50:28 AEDT ]]>